For cabinet boxes, plywood is usually the better long-term choice. It holds screws more securely, handles moisture better, and tends to stay stronger over time, especially in kitchens where humidity and daily wear are part of normal life. That’s a big reason why many custom cabinet makers prefer it.

Particleboard is less expensive, and it can work in some settings, but it’s more vulnerable to swelling and damage if moisture gets in. Once that happens, it tends to lose strength quickly.

The difference may not be obvious on day one, but it becomes much more noticeable over time — especially around sinks, dishwashers, and other areas where moisture is harder to avoid.